Only certain public health laboratories are able to provide the test after verifying that they can successfully perform the assay. Accessed February 2012. IgG antibodies are produced more slowly in response to an infection. luteocephalus. (Modified 2011 October 31). [49] Nonetheless, mouse studies suggest that IPS-1 is an important factor,[49] and that IRF3 and IRF7 are important in an age-dependent manner. IgM detection suggests infection within the previous 3 months. Accessed February 2012. [18][19][20] This condition has been termed chronic Chikungunya virus-induced arthralgia. [45] In mouse studies, deficiencies in INF-1 in mice exposed to the virus cause increased morbidity and mortality. Bingham AM, Cone M, Mock V, et al. [6] The virus may circulate within a number of animals including birds and rodents. [12] In Africa, outbreaks were typically tied to heavy rainfall causing increased mosquito population. In concurrent research, Robinson glossed the Makonde term more specifically as "that which bends up". Chikungunya virus infection should be considered in patients with acute onset of fever and polyarthralgia, especially travelers who recently returned from areas with known virus transmission. albopictus). ARUP Consult® assists with test selection and interpretation. © 2020 ARUP Laboratories. Stay indoors during dawn and dusk when mosquitoes are most active. Yes. [32], Chikungunya virus (CHIKV), is a member of the genus Alphavirus, and family Togaviridae. Molecular testing—a PCR test that detects the presence of the virus itself is generally considered the most reliable means of diagnosis. After a few months, IgM antibodies fall below detectable levels. Transmission via infected blood products and through organ donation is also theoretically possible during times of outbreak, though no cases have yet been documented. Are you an ARUP Client? This information can be used to help investigate outbreaks, identify and monitor infection sources, and to guide efforts to prevent the spread of the infection. Accessed February 2012. Testing should also be considered for other arthropod-borne viruses with similar symptomology based on clinical presentation and travel history. LabCorp COVID-19 Antibody Testing Available Nationwide Learn more >>>. The first recorded outbreak of this disease may have been in 1779. Available online at https://www.cdc.gov/dengue/. 2012 Yellow Book. A healthcare practitioner will consider a person's test results, medical history, and recent travel history in making a diagnosis. You will be subject to the destination website's privacy policy when you follow the link.
(© 1995–2012). This mutation potentially allows the virus to multiply more easily in mosquito cells. Saving Lives, Protecting People, instructions for sending diagnostic specimens to CDC, on-line CDC specimen submission form 50.34, Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), U.S. Department of Health & Human Services. World Health Organization Fact sheet. [11], Passive immunotherapy has potential benefit in treatment of chikungunya. [4] The very young, old, and those with other health problems are at risk of more severe disease. Upon infection with chikungunya, the host's fibroblasts produce type-1 alpha and beta interferon (IFN-α and IFN-β). Notify your state health department of any direct submissions to CDC. Kaye, K. (Revised 2009 December). Compliance Statement D: For laboratory tests using a manufactured RUO kit. Accessed February 2012. Jaypee Brothers Publishers. Accessed February 2012. [38] In those with chronic symptoms, a mild elevation of C-reactive protein (CRP) has been observed, suggesting ongoing chronic inflammation. As of 2017[update], no approved vaccines are available.
Overview of Arbovirus, Arenavirus, and Filovirus Infections. Arbovirus testing can also be performed on suspected host animals and mosquito pools to detect the presence and spread of an arbovirus in the community and region. ", "Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak", "A single mutation in chikungunya virus affects vector specificity and epidemic potential", "The Chikungunya epidemic in Italy and its repercussion on the blood system", "Identificado vírus causador de doença misteriosa em Salvador e RMS", "Chikungunya fever diagnosed among international travelers--United States, 2005-2006", "Chikungunya is NOT a Swahili word, it is from the Makonde language! Combatting Modern Slavery and Human Trafficking Statement, Africa, Asia, some in Southern Europe and the Caribbean. An additional blood sample may be collected 2 to 4 weeks later to determine if the antibody level is rising.
Available online at http://wwwnc.cdc.gov/travel/yellowbook/2012/chapter-3-infectious-diseases-related-to-travel/dengue-fever-and-dengue-hemorrhagic-fever.htm. Positive: Chikungunya IgG antibody detected; suggests current or past infection. Symptoms include fever and joint pains. [57] Serological diagnosis requires a larger amount of blood than the other methods, and uses an ELISA assay to measure chikungunya-specific IgM levels in the blood serum. During periods of epidemics humans are the reservoir of the virus. LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories. Available online at https://www.cdc.gov/dengue/resources/rt-pcr/cdcpackageinsert.pdf. Outbreaks where a large number of cases occur in a defined area are rare in the U.S. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897844/. Approximately 50 to 100 million symptomatic cases occur annually worldwide. (For more on the specific diseases related to your travels, visit the Destinations page on the Centers for Disease Control and Prevention web site.). Available online at http://www.cdc.gov/EasternEquineEncephalitis/tech/diagnosis.html. Accessed on 1/22/17. Clin Vaccine Immunol November 2001 vol. World Health Organization: Dengue.
Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/62869. Transfer 1 mL serum to an ARUP Standard Transport Tube.
0.80-1.09 Index: Equivocal: Questionable presence of Chikungunya IgG antibody detected. Accessed 6/1/2013. Available online at https://www.cdc.gov/zika/pdfs/denvchikvzikv-testing-algorithm.pdf. During the following week of recovery, a person may develop a second rash that lasts a week or more. [3] They mainly bite during the day.
Other names that describe the test. [4] This may be partly achieved by decreasing mosquitoes' access to water and with the use of insect repellent and mosquito nets. [10] In contrast to dengue fever, Chikungunya fever very rarely causes hemorrhagic complications. [75] The change allows the virus to use the Asian tiger mosquito (an invasive species) as a vector in addition to the more strictly tropical main vector, Aedes aegypti. Detection of Chikungunya Virus by this assay is based upon the real-time amplification of viral genomic RNA sequences from total nucleic acid extraction of the specimen.
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